This article reviews the effects of malnutrition on early brain development using data generated from animal experiments and human clinical studies. Three related processes, each with their own functional consequences, are implicated in the alteration of brain development. (1) Maternal undernutrition at the start of pregnancy results in reduced transfer of nutrients across the placenta, allowing the conservation of effort for future reproductive episodes. (2) Differential allocation to growing organs by the fetus in response to nutritional stress spares the brain (...) to a large though still limited degree, reflecting the organ’s relative contribution to survival and reproductive success. (3) Prenatal malnutrition disrupts developing neurotransmitter systems, which results in the expression of specific cognitive and affective traits. It is argued that the increasing size and therefore cost of the brain, in conjunction with increasing ecological instability and marginality, reinforced selection for maternally controlled growth suppression of offspring, reallocation of organ growth rates by offspring, and behavioral changes related to development of neurotransmitter systems. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:What Do You Mean, Rhetoric Is Epistemic?William D. HarpineIn 1967, Robert L. Scott (1967) advocated that "rhetoric is epistemic." This concept has enriched the work of rhetorical theorists and critics. Scott's essay is founded in a concept of argumentative justification in rhetoric, viewed as an alternative to analytic logic. Other writers, including Brummett (1976), Railsback (1983), and Cherwitz and Hikins (1986), have offered variations on Scott's theme. The (...) thesis that rhetoric is epistemic has been controversial, however, and from the tone of the debate one may draw two conclusions: many rhetorical theorists feel that Scott was on to something important, and the thesis as it has been developed is flawed. Much of the dispute centers on what the thesis means. These discussions have not yet adequately clarified that issue.The philosopher's most fundamental obligation is to define terms with care. It is in precisely this respect that the rhetoric-is-epistemic theorists have fallen short. Some of the key terms in this literature include rhetoric, knowledge, certainty, and truth. In too many cases, the writers on rhetorical epistemology have not defined their key terms at all. In other cases, their definitions are inadequate or inconsistent. This essay undertakes to sort out the most important definitional problems, which center on the rhetoric-is-epistemic theorists' habit of equivocating about the meanings of "rhetoric" and "certainty." The result makes it possible to endorse the validity of Scott's essentially ethical conclusions, while dismissing a number of unnecessary complexities in the arguments made by rhetoric-as-epistemic theorists. Finally, a few alternatives that might lead to more robust foundations for the rhetoric-as-epistemic thesis are suggested.In 1978, after reviewing four distinct interpretations of the claim that rhetoric is epistemic, Leff concluded that clarification of what that claim means "deserves more disciplined treatment than it has received in the recent literature" (1978, 77). The same could still be said. After some [End Page 335] thirty years of active research and speculation on the topic, one now sees fewer publications specifically advocating that rhetoric is epistemic. The distinguished rhetorical theorist Barry Brummett (1990) has declared the thesis deceased (69-72).All the same, textbook authors treat the thesis as a given, despite their tendency to interpret it in wildly different ways. Foss, for example, puts forward a view that "in the field of communication, the idea that rhetoric creates reality is known as the notion that rhetoric is epistemic, which simply means that rhetoric creates knowledge; epistemology is the study of the origin and nature of knowledge" (1989, 122; emphasis in the original). This version of the thesis, claiming that rhetoric actually "creates reality," might be more ontological than it is epistemic.1 Herrick takes a dialectical view that "through rhetorical interaction, people come to accept some ideas as true and to reject others as false. Thus, rhetoric's epistemic function in society can be seen in some ways to be a result of its benefit of testing ideas." Herrick continues that "once an idea has been tested thoroughly by a group, community, and society, it becomes part of what these groups take to be knowledge." Herrick contrasts this with the rejected view that "knowledge is all objective in nature and comes to us by way of direct experience or education" (1997, 22). Both Herrick and Foss offer interesting theses, and both attribute their views to Scott, but their views are obviously very different. There can be no surer evidence of the failure to use terms precisely.Brummett (1990) attributes the demise of rhetoric-is-epistemic research to the failure of critics to employ the idea in rhetorical criticism. Brummett might be right to the extent that much of the rhetoric-is-epistemic literature is indeed exceptionally abstract. Specific discussions might clarify some issues. Nonetheless, some notable rhetorical critics have indeed employed a concept that rhetoric is epistemic (e.g., Scott and Klumpp 1984; Sullivan 1992). The issues remain unclear. Furthermore, rhetorical criticism per se cannot clarify the meanings of theoretical terms. More likely, one sees less and less published research about the thesis that rhetoric is epistemic precisely because the thesis has not been laid out clearly... (shrink)

In Natural Ethical Facts William Casebeer argues that we can articulate a fully naturalized ethical theory using concepts from evolutionary biology and cognitive science, and that we can study moral cognition just as we study other forms of cognition. His goal is to show that we have "softly fixed" human natures, that these natures are evolved, and that our lives go well or badly depending on how we satisfy the functional demands of these natures. Natural Ethical Facts is a (...) comprehensive examination of what a plausible moral science would look like.Casebeer begins by discussing the nature of ethics and the possible relationship between science and ethics. He then addresses David Hume's naturalistic fallacy and G. E. Moore's open-question argument, drawing on the work of John Dewey and W. V. O. Quine. He then proposes a functional account of ethics, offering corresponding biological and moral descriptions. Discussing in detail the neural correlates of moral cognition, he argues that neural networks can be used to model ethical function. He then discusses the impact his views of moral epistemology and ontology will have on traditional ethical theory and moral education, concluding that there is room for other moral theories as long as they take into consideration the functional aspect of ethics; the pragmatic neo-Aristotelian virtue theory he proposes thus serves as a moral "big tent." Finally, he addresses objections to ethical naturalism that may arise, and calls for a reconciliation of the sciences and the humanities. "Living well," Casebeer writes, "depends upon reweaving our ethical theories into the warp and woof of our scientific heritage, attending to the myriad consequences such a project will have for the way we live our lives and the manner in which we structure our collective moral institutions.". (shrink)

Growth of the national cattle herd is contributing to rapid and inappropriate deforestation in Honduras. Field research was conducted in the Department of Olancho to better understand this problem and to assess the possibilities for local interest in forest protection. A recent upsurge in the profitability of cattle farming bodes badly for the forest, but three countervailing factors could ultimately serve as the basis for community-based forest management. First, area residents have a greater appreciation for the economic and ecological functions (...) of the forest than one might surmise, given the rapid pace of deforestation. Second, timber is a significant source of community income, thus there may be latent incentives to maintain supplies in the long term. Third, some residents will not turn to cattle farming, in spite of its profitability, perhaps because of their dependence on timber marketing. Policies enacted in 1992 undermine theseincipient incentives for forest custodianship. Inappropriate deforestation can be lessened through policy reforms thatwould enable smallholders to conserve and manage their resources over the long-term. (shrink)

The purpose of this article should become plain during the reading of it, but perhaps some prior explanation is needed. Almost from the beginning of my study of the paṭiccasamuppāda I have had the notion that it could not have come into existence in the form the usual twelvefold formulation takes. For reasons which I try to make clear this twelvefold formulation is not a satisfactory statement of what it is supposed to explain, namely the reasons for each individual's continued (...) rebirths. I feel - and sadly I have to emphasize, before someone else does it for me, that in the final analysis I am relying more or less on intuition for my attitude towards the twelvefold formulation - that if one person alone had been responsible for the usually referred to formulation, and especially if that one person had been the Buddha, then those anomalies that now prevail would never have existed. (shrink)

Michael Zbaraschuk’s recent article, “Not Radical Enough: William Dean’s Problems with God and History,”1 deserves a published response, because it applies not only to my work but to that of many other philosophical theologians, some of whom read this journal. Before discussing the larger issues, I must attend to an item of scholarly housekeeping. Although Zbaraschuk draws narrowly, i.e., from only two of my books—History Making History (1988) and The Religious Critic in American Culture (1994)—he applies his arguments indiscriminately (...) to my work as a totality, omitting most crucially the score of articles and the book written between 1994 and the present. Of course, there is nothing wrong with an .. (shrink)

Volume 24, Issue 7-8, November - December 2019, Page 871-872.

This chapter contains sections titled: Religious Thought as American Three Elements of American Religious Thought A Brief History The Waning of American Philosophy of Religion.

Intradermal capsaicin in humans causes pain, primary hyperalgesia, and secondary mechanical hyperalgesia and allodynia. Parallel changes occur in the responses of primate spinothalamic tract cells and in rat behavior. Neurotransmitters that trigger secondary mechanical hyperalgesia and allodynia include excitatory amino acids and substance P. Secondary mechanical allodynia is actively maintained by central mechanisms. Our group has investigated mechanisms of central sensitization of nociceptive neurons by examining the responses to intradermal injection of capsaicin. These experiments are pertinent to issues raised by (...) coderre & katz (sect. 2). (shrink)

The practice of inserting bits of lyric verse within Old French narrative romances appears to have begun with Jean Renart, the supposed author of the Roman de la rose ou de Guillaume de Dole, which most scholars date around 1228. It was soon imitated by Gerbert de Montreuil in his Roman de la violette and became widespread during the balance of the thirteenth and fourteenth centuries, appearing in upwards of fifty works. This technique of lyric insertions in romance continues the (...) earlier use of variable refrains within lyric songs and anticipates, perhaps, the insertion of snatches from Latin poetry in the Essais of Montaigne. Little studied until recently, the phenomenon was the focus of a colloquium at the Newberry Library in Chicago, in October 1991, with the title “Music and Narrative in Medieval Romance: The Poetics of Lyric Insertions.” The present study was read at that colloquium. (shrink)

Since the Great Recession of 2008–2009, practitioners of the liberal arts and sciences have experienced increasing pressure to demonstrate the relevance and value of liberal learning to working lives and careers. The economic crisis brought on by the COVID-19 pandemic is likely to increase that pressure. In this environment, how should defenders of the liberal arts and sciences be thinking about work and working lives? This essay attempts to answer that question by exploring broad trends in work and workplaces and (...) connecting those trends back to the traditional concerns of liberal learning. The essay also discusses some of the changes that will be necessary in the ways academic departments and college and university administrators think about the undergraduate curriculum. (shrink)

Early in Being and Time Heidegger announces that the primary concept by means of which he aims to understand Dasein is the concept to which he gives the name ‘existence.’ But what is existence? Existence is, roughly, that feature of Dasein that its self-understanding is constitutive of its being what or who it is. In an important sense, this concept embodies Heidegger’s existentialism. At the center of existentialism lies the claim that humans are given their content neither by an ahistorical, (...) transcultural essence, nor by nature. Rather, Dasein itself determines this content in its act of self-understanding. Kierkegaard expressed this in his famous formulation that “The self is that which relates itself to itself;” Ortega in his catchy phrase, “Man has no nature;” and Sartre in his notorious proposition, “Existence comes before essence.” All of these dicta articulate the same idea. (shrink)

In two articles, Smits, Buekens, and du Plessis have argued that John Searle’s account of institutional facts suffers serious flaws and should be replaced with a reductive account they call “incentivization.” We argue against their view in two ways. First, the specific flaws they find in Searle are based on misunderstandings. Second, “incentivization,” as they present it, fails as a reduction of strict collective actions and, thus, cannot account for institutional facts such as money or property.

The developing neuromuscular junction has provided an important paradigm for studying synapse formation. An outstanding feature of neuromuscular differentiation is the aggregation of acetylcholine receptors (AChRs) at high density in the postsynaptic membrane. While AChR aggregation is generally believed to be induced by the nerve, the mechanisms underlying aggregation remain to be clarified. A 43‐kD protein (43k) normally associated with the cytoplasmic aspect of AChR clusters has long been suspected of immobilizing AChRs by linking them to the cytoskeleton. In recent (...) studies, the AChR clustering activity of 43k has, at last, been demonstrated by expressing recombinant AChR and 43k in non‐muscle cells. Mutagenesis of 43k has revealed distinct domains within the primary structure which may be responsible for plasma membrane targeting and AChR binding. Other lines of study have provided clues as to how nerve‐derived (extracellular) AChR‐cluster inducing factors such as agrin might activate 43k‐driven postsynaptic membrane specialization. (shrink)

Jung's Psychology as a Spiritual Practice and Way of Life considers the pioneering depth-psychologist Carl Gustav Jung, primarily as a sage of world-class stature. The authors focus on Jung as an archetypal wisdom teacher, in three important respects: (1) in the post-modern West, primarily in interaction with Friedrich Nietzsche and his Thus Spake Zarathustra and also with theologian Paul Tillich and Zen master Karlfried Graf Durckheim; (2) in his deep spiritual kinship with the timeless universality of Lao-tze and his classic (...) The Tao Te Ching; and (3) in consideration of the future prospects of Jung's psychology in mind/body medicine, especially neuroscience, and in dialogue with quantum speculation. This book contends that Jung's psychology is not primarily a form of psychotherapy in the conventional sense but essentially a dynamic "religious philosophical system" constituting a spiritual practice and way of life. The dialogue format suggests not only Jung's own dialogue or "confrontation" with the Unconscious but also his generally unacknowledged spiritual affinity with the central Western philosophical tradition, a tradition stemming from Socrates and Plato and their devotion to the task of "living the questions.". (shrink)

The target article by Corballis presents an interesting and novel theoretical perspective on the evolution of language, speech, and handedness. There are two specific aspects of the article that will be addressed in this commentary: (a) the link between Broca's area and gestural communication in chimpanzees, and (b) the issue of population-level handedness in great apes, notably chimpanzees.

Blaise Pascal is highly regarded as a religious moralist, but he has rarely been given his due as an ethical theorist. The goal of this article is to assemble Pascal's scattered thoughts on moral judgment and moral wrongdoing into an explicit, coherent account that can serve as the basis for further scholarly reflection on his ethics. On my reading, Pascal affirms an axiological, social-intuitionist account of moral judgment and moral wrongdoing. He argues that a moral judgment is an immediate, intuitive (...) perception of moral value that we willfully disregard in favor of the attractive, though self-deceptive, deliverances of our socially constructed imaginations. We can deceive ourselves so easily because our capacity to evaluate goods is broken, a dark legacy of the fall. In the article's concluding section, I briefly compare Pascal to contemporary ethicists and suggest directions for future research. (shrink)

Game-theoretic explanations of behavior need supplementation to be descriptive; behavior has multiple causes, only some governed by traditional rationality. An evolutionarily informed theory of action countenances overlapping causal domains: neurobiological, psychological, and rational. Colman's discussion is insufficient because he neither evaluates learning models nor qualifies under what conditions his propositions hold. Still, inability to incorporate emotions in axiomatic models highlights the need for a comprehensive theory of functional rationality.

Some scholars have speculated whether the conservative New Testament Calvinistic scholar, Machen and the New Testament critical scholar, Bultmann attended Marburg University at the same time. We now know that they did. They even attended two courses together which were taught respectively by Weiss and Jülicher. Although these men were strong opposites with respect to the environment in which they were raised as well as their theological presuppositions and conclusions, they both enjoyed the engaging environment of Marburg as students. Mainly (...) using personal letters, we learn that a comparison of these two young students goes further than their theological and biblical interests. Both had encyclopedic academic interests which carried over into a fascinating interdisciplinary way of life. (shrink)

Both the Sarbanes–Oxley Act of 2002 and the Dodd-Frank Act of 2010 include clawback provisions that require executives to pay back incentive compensation earned on financial statements that are restated in a subsequent period. Such provisions intend to reduce unethical reporting behavior by executives who otherwise might be more inclined to misstate financial statements to boost incentive-based compensation. However, such provisions could promote rather than deter unethical behavior. In particular, Pyzoha :2515–2536, 2015) finds that, under certain conditions, executives are less (...) willing to restate financial statements in the presence of a clawback policy. Similarly, auditors might also act unethically by being less likely to propose restatements in the presence of clawbacks to avoid upsetting management. To examine this possibility, this study reports the results of three experiments that examine the effect of clawback provisions on auditor judgment. Contrary to expectations, our three experiments, along with supplemental qualitative evidence consistently indicate that clawbacks do not affect auditors’ propensity to propose restatements. These results suggest that a decrease in the number of restatements in a clawback environment will not be due to auditors acting unethically to appease management. The effects of clawbacks on auditors’ risk assessments, however, are less conclusive. As such, we offer potential post hoc explanations to guide future research. (shrink)